EduBourseActualitésCelyad Announces Oral Presentation on NKR-2 T Cells Manufacturing for a First-in-Human...

Celyad Announces Oral Presentation on NKR-2 T Cells Manufacturing for a First-in-Human Clinical Trial in AML and Multiple Myeloma

Dernière mise à jour: octobre 21, 2021

Mont-Saint-Guibert, Belgium – Celyad (Euronext Brussels and Paris, and NASDAQ: CYAD), a leader in the discovery and development of engineered cell therapies, with clinical programs in cardiovascular diseases and immuno-oncology, today announced that an oral presentation titled “Validation of Manufacturing NKG2D Chimeric Antigen Receptor T Cells for a First-in Human Trial in AML/MDS and Multiple Myeloma” will be made at the American Society of Gene & Cell Therapy (ASGCT) 19th Annual Meeting May 4-7 in Washington DC.

Dr. Frédéric Lehmann, Head of Immuno-Oncology at Celyad: “We are pleased that the application to present the validation of our cell manufacturing process was selected for an oral presentation. It highlights the importance and interest in our NKR-2 clinical program marking a positive step forward. This technology has great potential and we are looking forward to completing the Phase I.”

About Celyad’s NKR-T program
NKR stands for Natural Killer Receptor. NKG2D CAR T-cells are now called NKR-2 T-cells and the product development name is NKR-2.

Existing CAR-T cells are engineered using constructs encoding an antibody single chain variable fragment, the signaling domain of CD3 zeta and one or more co-stimulatory domain(s). In contrast to existing CAR-T cells, Celyad’s lead immuno-oncology product candidate, NKR-2, is a T-Cell encoded to express the human Natural Killer activating receptor, NKG2D. Using the human Natural Killer cell receptor, unlike traditional CAR technologies, has the potential to:

 Bind to 8 different ligands that are expressed by a vast majority of cancer cells, both hemaetological and solid malignancies.

 Target and kill tumors as well as the blood vessels that feed them and also express the ligands of the NKG2D receptor.

 Target and kill the inhibitory mechanisms preventing the tumor from evading the immune system.

 Induces adaptive auto-immune response thanks to the creation of a long term cell memory against the targeted tumor.

The research underlying this technology was originally conducted by Dartmouth College Professor Charles Sentman, and has been published in numerous peer-reviewed publications. NKR-2 has an active Investigational New Drug (IND) application with the FDA for a Phase I clinical trial. The full data readout from the Phase I dose escalation trial is expected in mid-2016.

The trial is designed to assess the safety and feasibility of NKR-2 in acute myeloid leukemia and multiple myeloma patients, with secondary endpoints including clinical activity. The safety follow-up period post-infusion has been decreased to 21 days after approval by the U.S. Food and Drug Administration (FDA) and Institutional Review Board (IRB).

Pierre Perrin-Monlouis
Pierre Perrin-Monlouis
Fondateur de Rente et Patrimoine (cabinet de gestion de patrimoine), Pierre Perrin-Monlouis est un analyste et trader pour compte propre. Il vous fait profiter de son expérience en trading grâce à ses analyses financières et décrypte pour vous les actualités des marchés. Son approche globale des marchés combine à la fois l'analyse technique et l'analyse fondamentale sur l'ensemble des marchés : crypto, forex, actions et matières premières.